Search results for "sublingual absorption"

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Development and Characterization of an Amorphous Solid Dispersion of Furosemide in the Form of a Sublingual Bioadhesive Film to Enhance Bioavailabili…

2017

Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoadhesive sublingual fast-dissolving FUR based film has been developed and evaluated in order to optimize the bioavailability of FUR by increasing solubility and guaranteeing a good dissolution reproducibility. The Differential Scanning Calorimetry (DSC) analyses confirmed that the film prepared using the solvent casting method entrapped FUR in the amorphous state. As a solid dispersion, FUR increa…

Absorption (pharmacology)medicine.medical_specialtymucoadhesive filmMaterials scienceBioadhesivePharmaceutical Sciencelcsh:RS1-44102 engineering and technology030226 pharmacology & pharmacyArticleSublingual Absorptionlcsh:Pharmacy and materia medica03 medical and health sciences0302 clinical medicineDifferential scanning calorimetryamorphous solid dispersiontransmucosal deliverymedicineSolubilityDissolutionAmorphous solid dispersion; Furosemide bioavailability; Mucoadhesive film; Sublingual absorption; Transmucosal delivery;021001 nanoscience & nanotechnologyfurosemide bioavailabilityAmorphous solidSurgeryBioavailabilitysublingual absorptionChemical engineeringSettore CHIM/09 - Farmaceutico Tecnologico Applicativomucoadhesive film; sublingual absorption; amorphous solid dispersion; furosemide bioavailability; transmucosal delivery0210 nano-technologyPharmaceutics

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